illuminating altered metabolic signaling in cancer

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People

 

Liron Bar-Peled

lbar-peled@mgh.harvard.edu

Liron received his Bachelor of Science degree in Biochemistry from the University of Georgia in 2004. Liron received his PhD in Biology from the Massachusetts Institute of Technology, where he used advanced cellular and molecular techniques to uncover how nutrients are sensed by the mTORC1 pathway in the laboratory of David Sabatini.

In 2013 as a Damon Runyon Postdoctoral fellow, he joined the laboratory of Ben Cravatt at the Scripps Research Institute to understand how cancer cells respond to oxidative stress. Employing chemical, proteomic and biochemical approaches, Liron revealed new druggable components of the NRF2 antioxidant response pathway uncovering new mechanisms by which NRF2 regulates metabolic pathways.

In early 2019, Liron joined the Center for Cancer Research at the Massachusetts General Hospital and the Department of Medicine at Harvard Medical School.

 
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Lab Members

 

Ben Jiang

Masters Student (bjiang6@mgh.harvard.edu)

Ben is a biochemistry student from German currently enrolled at the Technical University of Munich. He received his bachelor's degree in 2016 working on the colon cancer suppressor and E3 ligase RNF43. His current project focuses on developing chemical and genetic tools to study transcriptional drivers in genetically defined cancers. He likes to go jogging and plays badminton or ultimate-frisbee. Luckily, there are online streaming services available for the colder seasons.

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Marion Schweiger

Masters Student (MSCHWEIGER1@mgh.harvard.edu)

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Marions is a molecular biotechnology masters student from Germany currently enrolled at the Technical University of Munich. She received her bachelor's degree in 2017 working on targeted mutagenesis for metabolic engineering in E.coli. Her current project focuses on developing chemical and genetic tools to aberrant signaling pathways in cancer. In her free time she enjoys meeting friends, going to the gym and skiing in the winter.

 

Abby Smith

Research Technician I (ASMITH130@mgh.harvard.edu)

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Abby grew up in Georgia, where she received her Bachelor of Science in Biology from the University of Georgia. Abby conducted research in Maor Bar-Peled’s lab investigating key regulators of an exopolysaccharide in Baccilus. Abby plans on attending medical school in the near future and during her free time she enjoys jogging, tennis and going to concerts.

 

Tommy Weiss-Sadan

Postdoctoral Fellow (TWEISSSADAN@mgh.harvard.edu)

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Tommy received his Ph.D. from the Hebrew University where he studied the involvement of lysosomal cysteine proteases in vascular inflammation and cell metabolism. Now, he employs powerful genetic and proteomic techniques to investigate how cancer cells exploit ROS signaling mechanisms for proliferation. During his free time, Tommy enjoys being with his family and outdoor activities.  

 

Konstantin Wolf

Masters Student (KWOLF4@mgh.harvard.edu)

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Konstantin is a Biotechnology master’s student currently enrolled at ETH Zürich. He holds two bachelor’s degrees in Biochemistry and Bioprocess Engineering from Technical University of Munich. He graduated in Biochemistry in 2016 working on the uptake of human Hepatitis B Virus in hepatocytes with a major focus on the role of the L-protein of HBV. Konstantin finished his second bachelor’s degree in 2017 with a project about cross-linked enzyme aggregates of enreductases. In his free time, he enjoys hiking, playing music and traveling to other countries.

 

Mengyao Xu

Graduate Student collaborator with David Spriggs (MXU18@mgh.harvard.edu)

Mengyao Xu received her Bachelor of Clinical Medicine followed by a Master’s degree in OB/GYN from Third Military Medical University in China. She is currently a third year PhD candidate at Nankai University School of Medicine, working in gynecologic oncology, specifically ovarian cancer. In her free time she enjoys traveling, hiking, skiing, trying different kinds of food, she is also a great fan of fashion and cooking. 



 
 



Junbing Zhang

Postdoctoral Fellow (JZHANG75@MGH.HARVARD.EDU)

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Junbing received his PhD from National Institute of Biological Science and Institute of Biophysics, China. He studied membrane trafficking in C.elegans and mammalian cells during his PhD. Now he is interested ROS signaling in cancer and will employ powerful genetic and chemical proteomic approaches to identify local ROS sensors involved in NRF2 activation.  During his free time, he likes playing online games, watching movies and swimming.