illuminating altered metabolic signaling in cancer




Selected Publications

Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB 3rd, To A, Parsons WH, Simon GM, Desai A, Petrascheck M#, Bar-Peled L#, Cravatt BF*. Pharmacological convergence reveals a lipid pathway that regulates C. eleganslifespan. Nat Chem Bio, In press.  

Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M.(2018). Translation attenuation by minocycline enhances longevity and proteostaiss in old post-stress-responsive organisms. eLife 7:e40314. 

Lamming DW, Bar-Peled L. (2018). Lysosome: The metabolic signaling hub. Traffic (1): 27-38

Bar-Peled L.*#, Kemper E. K*., Suciu R. M, Vinogradova E. V., Backus K. M., Horning ¬B. D., Paul T. A., Ichu T-A., Svensson R. U., Olucha J., Chang M. W., Kok B. P., Zhou Z., Ihle N., Dix M. M., Hayward M., Jiang P., Saez E., Shaw R. J., and Cravatt B. F.# (2017). Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell 171: 696-709.

Schweitzer L.D., Comb W.C., Bar-Peled L., and Sabatini D.M. (2015). Disruption of the Rag-Ragulator complex by c17orf59 inhibits mTORC1. Cell Rep. 12: 1445-55.

Wang S., Tsun Z-Y., Wolfson R.W., Shen K., Wyant G. A., Plovanich M.E., Yuan Y.D., Jones T. D., Chantranupong L., Comb W., Wang T., Bar-Peled L., Zoncu R., Straub C., Kim C., Park J., Sabatini B.L., and Sabatini D.M. (2015) The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1. Science. 347: 188-194.
Comment in: 
Cell biology: Making sense of amino acid sensing (Science 2015)

Bar-Peled L. (2014). Size does matter. Science 346: 1191-1192.
Comment in: 
Science 2014:

Chantranupong L., Wolfson R.L., Orozco J.M., Saxton R.A., Scaria S.M., Bar-Peled L., Spooner E., Isasa M., Gygi S.P., Sabatini D.M. (2014). The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 9: 1-8.

Bar-Peled L. and Sabatini D.M. (2014). Regulation of mTORC1 by amino acids. Trends in Cell Biol. 7: 400-406.

Tsun Z-Y., Bar-Peled L.*, Chantranupong L.*,  Zoncu R., Wang T.,  Kim C., Spooner E., Sabatini D.M. (2013). The Folliculin Tumor Suppressor is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1. Molecular Cell 52: 495-505.
Comment in: 
Signaling: Finding the GAPs in mTORC1 signaling (Nat. Rev Cancer 2013)

Bar-Peled L.*,Chantranupong L.*, Cherniack A. D., Chen W. W., Ottina K. A., Grabiner, Spear E. A., Carter S. L., Meyerson M. L., and Sabatini D. M. (2013). A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 340: 1100-1106.
Comment in: 
Cell Biology. GATORs take a bite out of mTOR (Science 2013)

Bar-Peled L. and Sabatini D.M. (2012). mTORC1 signaling at the lysosomal surface. Cell 151: 1390-1390e1.

Bar-Peled L., Schwietzer L. D., Zoncu R., and Sabatini D.M. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1 (2012). Cell 150: 1196-1208.

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., Sabatini, D.M., (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase. Science 334: 678-683.
Comment in:
Cell biology. Growth signaling from inside (Science 2011)

Sancak, Y.*, Bar-Peled, L.*, Zoncu, R., Markhard, A.L., Nada, S. and Sabatini, D.M. (2010) Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids. Cell 141: 290-303.
Comment in: 
Lysosomal Rag-ulation of mTOR complex 1 activity (Cell Metab. 2010):
Cell signaling: Of Rags and Ragulator (Nat Rev Mol Cell Biol. 2010):

Yang T., Bar-Peled, L., Gebhart L., Lee S.G., Bar-Peled M. (2009). Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants and comparison with galactose-1-phosphate kinase. J. Biol. Chem. 284: 21526-21535.

Sancak, Y., Peterson, T.R., Shaul, Y.D., Lindquist, R.A., Thoreen, C.C., Bar-Peled, L., and Sabatini, D.M. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501.

*These authors contributed equally to this work
#Co-corresponding authors